New reagents for detecting free radicals and oxidative stress.

Oxidative Stress and Human Disease: a Review

Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...

Diabetes and Oxidative Stress: The Mechanism and Action

Abstract Diabetes mellitus is one of the major metabolic disorders. Diabetes is recognized for severe complications including diabetic nephropathy, neuropathy and retinopathy. Long-lasting effect of hyperglycemia results in increased oxidative stress. Oxidative stress results from an imbalance between radical-generating and radical scavenging systems. Increased oxidative stress has been shown ...

Role of oxygen and nitrogen free radicals in diabetes-induced atherosclerosis and effects of exercise on it

Free radical can be defined as a molecule or molecular fragments containing unpaired electron in the outer orbital, which react with nearby molecules to get stability. There are two types of them in the body: oxygen free radicals and nitrogen free radicals. Our body has an antioxidant defense system which prevents accumulation of these radicals. There is a balance between free radical produc...

P-216: Dual Targeting of TNF-? and Free Radicals Toxic Stress as A Promising Strategy to Manage Experimental Polycystic Ovary

Oxidative Stress and its Role in Female Infertility and Assisted Reproduction: Clinical Implications

Reactive oxygen species (ROS) are involved in physiological functions and act as mediators in various signaling processes. Elevated or sustained generation of free radicals and non radical species derived from free radicals can lead to an imbalance in the intracellular redox homeostasis. Normally, any excess levels of reactive radical and nonradical species generated are intercepted by antioxid...